Bartter’s Syndrome, 1962

Hyperplasia of the Juxtaglomerular Complex with Hyperaldosteronism and Hypokalemic Alkalosis, A New Syndrome

Frederic C. Bartter M.D.

HYPERPLASIA and hypertrophy of the juxtaglomerular apparatus, and primary aldosteronism with hypokalemic alkalosis were found associated with normal blood pressure in two patients [1] . This coexistence of a histologic lesion not previously described with a rare disease entity suggests an association between them; the appearance of these disorders in two patients who have never had hypertension appears to represent a new syndrome.

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Bartter Abstracts

Medical journals online will show a summary of medical articles. The summary is called an “abstract”. Sometimes just reading the abstract will tell you enough. Sometimes after reading an abstract you might want to read the full article. Then you can go to a medical library or public library and ask them to obtain the article for you. There are 23 abstracts listed.

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Bartter’s Syndrome

Bartter’s Syndrome is an inherited defect in the renal tubules that causes low potassium levels, low chloride levels, which in turn causes metabolic alkalosis. Bartter Syndrome, is not a single disorder but rather a set of closely related disorders. These Bartter-like syndromes share many of the same physiologic derangements, but differ with regard to the age of onset, the presenting symptoms, the magnitude of urinary potassium (K) and prostaglandin excretion, and the extent of urinary calcium excretion.

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Antenatal Bartter Syndrome

What is Antenatal Bartter’s?

In contrast to Classic Bartter Syndrome and Gitelman Syndrome, the Antenatal variant of Bartter Syndrome has both the features of metabolic alkalosis (from the low potassium), as well as profound systemic manifestations. Out of all of the variants this form is the most severe.

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Full Journal Articles

On this page we have full journal articles of the selected topics. These are not as easy to create or find so I don’t have as many of them as I do the abstracts. There are 22 articles listed.

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Antenatal Bartter Syndrome, Information for Medical Personnel

In contrast to Classic Bartter Syndrome and Gitelman Syndrome, the Antenatal variant of Bartter Syndrome has both the features of renal tubular hypokalemic alkalosis as well as profound systemic manifestations. Antenatal Bartter Syndrome is characterized by polyhydraminos due to intrauterine polyuria, and premature delivery is common. After birth, life-threatening episodes of fever and dehydration occur secondary to profound polyuria, vomiting, and diarrhea.

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New Treatment Options for Bartter’s Syndrome

The New England Journal of Medicine
August 31, 2000 — Vol. 343, No. 9

Letter To the Editor:

Bartter’s syndrome is a major cause of congenital salt wasting. As a consequence of abnormal salt reabsorption in the thick ascending limb of Henle’s loop due to mutations in the luminal sodium-potassium-2-chloride cotransporter (antenatal Bartter’s syndrome type I), the luminal potassium channel (antenatal Bartter’s syndrome type II), or the basolateral chloride channel (classic Bartter’s syndrome type III), the activity of the renin-angiotensin-aldosterone system increases. (1) Prostaglandins increase as a consequence of volume contraction, and this increase may itself stimulate renin secretion. (2) Unfortunately, prostaglandins block salt reabsorption by mechanisms that are not yet fully understood. (1)

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Testing for Bartter Syndrome

If patients, especially dehydrated infants and young children, are found to have hypokalemia and a high serum bicarbonate concentration on routine labs and do not correct with potassium and chloride replacement treatment, consider possible renal tubular disorder.

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Survey Results

Results from Mail in Survey

One thing I have noticed in doing the surveys is that the older a person gets the more symptoms they have. A small child has very few which is probably because mom does not know what that child is truly feeling. In the teens the symptoms increase but only slightly. In the 20′s a slight increase and then in the 30′s the person has 10 or more symptoms. By the 40′s the person has most of the symptoms listed below. This could be because the person has had it longer so they are more aware of their symptoms or it could be that as we age the symptoms will increase.

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