Inherited Disorders of Renal Magnesium Handling

Conclusion

In summary, the molecular and genetic basis of various inherited disorders that affect renal magnesium handling are being delineated. These conditions affect different nephron segments and different cell types, which leads to variable but increasingly distinguishable phenotypic presentations. Undoubtedly, there are other disorders in the general population that have not yet been identified or characterized. The continued use of molecular techniques to probe the constitutive and congenital disturbances of magnesium metabolism will increase our understanding of cellular magnesium transport and provide new insights into the way these diseases are diagnosed and managed.

Credits and Acknowledgments

Journal of the American Society of Nephrology
Volume 11 Number 10 October 2000
Copyright 2000 American Society of Nephrology

David E. C. Cole
Gary A. Quamme

Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, and Department of Medicine, University of British Columbia, Koerner Pavilion, University Hospital, Vancouver, British Columbia, Canada.
April 13, 2000.

Copyright 2000 by the American Society of Nephrology

We thank Iwan C. Meij for reading parts of this review. This work was supported by research grants from the Medical Research Council of Canada (MT-5793) and from the Kidney Foundation of Canada to G.A. Quamme and from NSERC and Dairy Farmers of Canada to D.E.C. Cole.

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