A Case of Neonatal Bartter’s Syndrome

We describe a child with a neonatal presentation of Bartter’s syndrome. Unlike infants previously described with a similar clinical presentation, the urinary excretion rate of prostaglandin E2 in this child was similar to normal children and Tamm-Horsfall protein was distributed normally in the thick ascending limb of the loop of Henle. The child failed to respond to indomethacin alone, but thrived after the addition of the angiotensin converting enzyme inhibitor, captopril.

Abstract

Volume 10 Issue 4 (1996) pp 414-418
W. Wong (1) (*), S.-A. Hulton (1), C. M. Taylor (1), F. Raafat (2), C. J. Lote (3), G. Lindop (4)

(1) Department of Nephrology, Birmingham Children’s Hospital NHS Trust, Ladywood Middleway, Birmingham, B16 8ET, UK
(2) Department of Histopathology, Birmingham Children’s Hospital NHS Trust, Ladywood Middleway, Birmingham, B16 8ET, UK
(3) Department of Physiology, University of Birmingham, The Medical School, Birmingham, B15 2TT, UK
(4) Department of Pathology, Western Infirmary, Glasgow, G11 6NT, UK

Received March 20, 1995; received in revised form and accepted February 23, 1996

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